Unrest at home: diarrheal disease and microbiota disturbance

Unrest at rest: Default activity and spontaneous network correlations

A series of recent empirical observations demonstrate structured activity patterns that exist during passive task states. One observation is that a network of regions, referred to as the default network, shows preferentially greater activity during passive task states as compared to a wide range of active tasks. The second observation is that distributed regions spontaneously increase and decre...

Escherichia Coli in Diarrheal Disease

Transmission is by the fecal-oral route. Pili (fimbriae) allow the bacteria to colonize the ileal mucosa. Cytotonic enterotoxins (encoded on plasmid or bacteriophage DNA) induce watery diarrhea. Plasmid-encoded invasion factors permit invasion of the mucosa, and plasmidor bacteriophage-encoded cytotoxic enterotoxins induce tissue damage; the presence of either of these factors induces a host in...

Diarrheal Disease and Childhood Pneumonia in Cambodia

The vast majority of deaths from diarrhea occur in low-resource countries such as Cambodia, where families are at high risk for the disease as a result of living in poor sanitary conditions and not having access to safe water or to lifesaving treatment. Malnourished children are most at risk of dying due to severe diarrhea and a general lack of understanding among parents about the causes, symp...

Parasitic diarrheal disease: drug development and targets

Diarrhea is the manifestation of gastrointestinal infection and is one of the major causes of mortality and morbidity specifically among the children of less than 5 years age worldwide. Moreover, in recent years there has been a rise in the number of reports of intestinal infections continuously in the industrialized world. These are largely related to waterborne and food borne outbreaks. These...

Rotavirus genotypes and severity of diarrheal disease.